Erlang renewal models for genetic recombination

Erlang renewal models for genetic recombination

Closed form expressions for multilocus probabilities are given for the crossover process when it is a renewal process with the distance between crossovers modeled by a Erlang distribution. Closed form expressions are also given for the multilocus probabilities for the chiasma process on the four strand bundle under the same model of recombination for single gamete and for tetrad data. These exp...

The Spectrum of Intervals for Super . Posed Erlang Renewal Processes

Evaluating the Erlang C and Erlang A Models for Call Center Modeling

We consider two queuing models commonly used to analyze call centers; the Erlang C and Erlang A models. The Erlang C is a very simple model that ignores caller abandonment and is the model most commonly used by practitioners and researchers. The Erlang A model allows for abandonment, but performance measures are more difficult to calculate. Several recent papers have advocated the use of the Er...

Molecular basis for genetic recombination.

HE past few decades have witnessed the successive description in biochemiTcal-or “molecular”-terms of the great formal entities of classical genetics. The lickage group was early identified with the objectively seen chromosome, then the gene itself, in its wild and mutant forms, more and more closely related to the linear DNA regions thereof. We have seen the identification of the gene product ...

Molecular mechanism for genetic recombination.

Symmetry considerations of proteinnucleic acid interaction suggest the existence of an alternate branched configuration for DNA induced by binding specific structural proteins to symmetrically arranged polynucleotide base sequences. The concept that such sequences exist at the ends of genes or operons leads to a molecular model for genetic recombination in eukaryotic cells.